A simple, accurate, precise and specific spectrophotometric method has been developed for simultaneous determination of racecadotril and ofloxacin in its combined tablet dosage form by using methanol as a solvent. The method involves solving of simultaneous equation based on measurement of absorbance at two wavelengths at 206.5 nm and 227.6 nm. Method follows Beer’s linearity in the range of 5-12 μg/ml for racecadotril and 10-24 μg/ml ofloxacin both. The mean % recoveries were found to be in the range of 99.04–101.4% and 98.85 – 101.6% for racecadotril and ofloxacin respectively. Limit of detection and quantitation was found to be 0.031 μg/ml and 0.096 μg/ml for racecadotril and 0.043 μg/ml and 0.131μg/ml for ofloxacin respectively. Assay results of market formulation were found to be 99.64% and 99.82% for racecadotril and ofloxacin respectively. The proposed method has been validated as per ICH guidelines and successfully applied to the estimation of racecadotril and ofloxacin in their combined tablet dosage form.
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